Carbohydrates are ubiquitous in all biological systems. Cells carry a carbohydrate-dense outer membrane called the glycocalyx, and many proteins and lipids are glycosylated. These carbohydrates serve as recognition sites for cells, microorganisms, toxins and other biomolecules. The field of glycomics enables understanding of the structures, significance and roles of carbohydrates in interactions with other biomolecules (the glycointeractome). This presentation will feature case studies that demonstrate the power of the glycomics discovery pipeline to deliver new opportunities to understand, diagnose, prevent and cure infectious disease.